Asymmetric synthesis of acyclic N–N axially chiral indole compounds via catalytic N-acylation reaction

Herein, we present a highly enantioselective synthesis of N-aminoindoles containing N–N axis by chiral isothioureas (ITUs) catalyzed asymmetric N-acylation of N-aminoindoles with anhydrides, producing a series of N–N axially chiral...