神经退行性变
神经科学
线粒体
医学
程序性细胞死亡
生物信息学
疾病
心理学
生物
细胞凋亡
细胞生物学
病理
遗传学
标识
DOI:10.3389/fnins.2019.01372
摘要
Neurodegenerative diseases are incurable and inexorably progressive conditions that affect the central content that is a critical determinant of sensitivity to ferroptotic cell death (Doll et al., 2017). Therefore, it has been suggested that compounds which target Nrf2 may counteract ferroptotic-mediated neuronal loss and exert beneficial effects in the treatment of neurogenerative diseases (Abdalkader et al., 2018).Although pathologically-related aggregate species of α-syn, Aβ and tau regulate lipid peroxidation, glutathione levels, and iron homeostasis, as yet no studies have explored their potential role in ferroptotic cell death.In conclusion, this special issue provides scientists and clinicians with new insights into the molecular mechanisms underlying the role of mitochondrial dysfunction in the pathophysiology of neurodegenerative diseases such as PD and AD. Furthermore, it may provide further rationale for the development of effective therapeutic interventions targeting mitochondria to treat these devastating illnesses.VT confirms being the sole contributor of this work and has approved it for publication.I would like to thank you the authors, editorial team members of Frontiers, and especially the reviewers for helping to set the highest quality standards.The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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