Synthesis of 1-aroylmethylpyrroles as useful intermediates for further chemical transformation

The synthesis of 1-aroylmethylpyrroles from 2-bromo-1-(2-aminophenyl)ethan-1-one and monodior tri-substituted 1H-pyrroles, has been investigated. The reactions take place at r.t. or 80 C in DMF containing potassium carbonate. Reduction of 1-[2-(2-aminophenyl)-2-oxoethyl]-4bromo-1Η-pyrrole-2-carbaldehyde with sodium borohydride gave racemic 1-(2-aminophenyl)-2[4-bromo-2-(hydroxymethyl)-1Η-pyrrol-1-yl]ethanol.