口腔给药
生物利用度
药物输送
黏膜黏附
粘附
离体
药品
纳米技术
材料科学
粘液
胶粘剂
生物医学工程
药理学
体内
毒品携带者
医学
生物
复合材料
生物技术
图层(电子)
生态学
作者
Shanshan Hu,Xibo Pei,Lunliang Duan,Zhou Zhu,Yanhua Liu,Junyu Chen,Tao Chen,Ping Ji,Qianbing Wan,Jian Wang
标识
DOI:10.1038/s41467-021-21989-5
摘要
Abstract Administration of drugs via the buccal route has attracted much attention in recent years. However, developing systems with satisfactory adhesion under wet conditions and adequate drug bioavailability still remains a challenge. Here, we propose a mussel-inspired mucoadhesive film. Ex vivo models show that this film can achieve strong adhesion to wet buccal tissues (up to 38.72 ± 10.94 kPa). We also demonstrate that the adhesion mechanism of this film relies on both physical association and covalent bonding between the film and mucus. Additionally, the film with incorporated polydopamine nanoparticles shows superior advantages for transport across the mucosal barrier, with improved drug bioavailability (~3.5-fold greater than observed with oral delivery) and therapeutic efficacy in oral mucositis models (~6.0-fold improvement in wound closure at day 5 compared with that observed with no treatment). We anticipate that this platform might aid the development of tissue adhesives and inspire the design of nanoparticle-based buccal delivery systems.
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