Coprococcus protects against high-fat diet-induced nonalcoholic fatty liver disease in mice

非酒精性脂肪肝 非酒精性脂肪性肝炎 脂肪肝 生物 微生物学 食品科学 疾病 医学 内科学
作者
Kaikai Lu,Yimeng Zhou,Lei He,Ya Li,Muhammad Shahzad,Dongmin Li
出处
期刊:Journal of Applied Microbiology [Wiley]
卷期号:135 (6)
标识
DOI:10.1093/jambio/lxae125
摘要

Abstract Aims The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing annually, leading to substantial medical and health burdens. Numerous studies have demonstrated the potential effectiveness of intestinal probiotics as a treatment strategy for NAFLD. Therefore, the objective of this study is to identify a probiotic for the treatment of NAFLD. Methods and results In this study, blood and fecal samples were collected from 41 healthy volunteers and 44 patients diagnosed with NAFLD. Analysis of the 16S rDNA sequencing data and quantitative real-time PCR (RT-qPCR) revealed a significant reduction in the abundance of Coprococcus in NAFLD patients. Subsequent animal experiments demonstrated that Coprococcus was able to effectively reverse liver lipid accumulation, inflammation, and fibrosis induced by a high-fat diet (HFD) in mice. Conclusions This study provides the first in vivo evidence that Coprococcus is a beneficial bacterium capable of preventing NAFLD and has the same probiotic effect in mice as Lactobacillus GG (LGG), a positive control. Therefore, Coprococcus has the potential to serve as a probiotic for the prevention and treatment of NAFLD in humans.
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