抗菌活性
生物安全
细菌
致病菌
细胞毒性
纳米技术
化学
组合化学
材料科学
生物
生物化学
生物技术
遗传学
体外
作者
Zeyan Zhuang,Zijuan Meng,Jianqing Li,Pingchuan Shen,Jun Dai,Xiaoding Lou,Fan Xia,Ben Zhong Tang,Zujin Zhao
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-08-02
卷期号:16 (8): 11912-11930
被引量:27
标识
DOI:10.1021/acsnano.2c01721
摘要
To address the threat of bacterial infection in the following post-antibiotic era, developing effective antibacterial approaches is of utmost urgency. Theranostic medicine integrating diagnosis and therapy is a promising protocol to fight against pathogenic bacteria. But numerous reported antibacterial theranostic materials are disclosed to be trapped in the excessive invasiveness to living mammal cells, leading to false positives and possible biosafety risks. Herein, a series of cationic pyridinium-substituted phosphindole oxide derivatives featuring aggregation-induced emission are designed, and alkyl chain engineering is conducted to finely tune their hydrophobicity and investigate their bioaffinity preference for living mammal cells and pathogenic bacteria. Most importantly, an efficient theranostic agent (PyBu-PIO) is acquired that is free from living cell invasiveness with negligible cytotoxicity and yet holds a good affinity for Gram-positive bacteria, including drug-resistant strains, with a superior inactivating effect. Externally applying PyBu-PIO onto Gram-positive bacteria-infected skin wounds can achieve creditable imaging effects and successfully accelerate the healing processes with reliable biosafety. This work proposes living cell invasiveness as a criterion for antibacterial theranostic materials and provides important enlightenment for the design of antibacterial theranostic materials.
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