Clinical correlates and prognostic value of different metastatic sites in metastatic renal cell carcinoma

医学 肿瘤科 内科学 比例危险模型 肾细胞癌 转移 多元分析 监测、流行病学和最终结果 阶段(地层学) 肾癌 癌症 淋巴结 肾透明细胞癌 癌症登记处 生物 古生物学
作者
Omar Abdel‐Rahman
出处
期刊:Future Oncology [Future Medicine]
卷期号:13 (22): 1967-1980 被引量:43
标识
DOI:10.2217/fon-2017-0175
摘要

Aim: Real life data on the clinical correlates and prognostic value of metastatic sites in metastatic renal cell carcinoma (RCC) are needed. This parameter was assessed in RCC patients registered within the surveillance, epidemiology and end results (SEER) database. Methods: Data were obtained from the National Cancer Institute-SEER database spanning 2010-2013; and it has been accessed through SEER*Stat program to determine the clinical correlates and prognosis of RCC patients with distant metastases according to the site of metastasis. Multivariate analyses were performed using Cox regression analysis to determine factors associated with improved overall and cancer-specific survival. Kaplan-Meier curves and log-rank tests were used to calculate and compare survival estimates. Results: A total of 5992 patients with metastatic RCC were identified in the period from 2010 to 2013. Patients with isolated liver metastases have worse survival outcomes compared with patients with other single organ sites of metastases. Pairwise p-values for cancer-specific survival: bone metastasis versus liver metastasis: p < 0.0001; lung metastasis versus liver metastasis: p = 0.002; distant lymph nodes versus liver metastasis: p = 0.006. Multivariate analysis revealed that younger age at diagnosis (p < 0.0001), single organ site of metastatic disease (p = 0.046), male gender (p = 0.001), earlier T stage (p < 0.0001), node negative status (p < 0.0001), clear cell histology (p = 0.001), local treatment to the primary tumor (p < 0.0001) and surgery to the metastatic disease (p < 0.0001) were associated with better overall survival. The same factors (except age) were associated with better cancer-specific survival. Conclusion: Metastatic RCC patients with liver metastases seem to have worse outcomes compared with patients with other sites of metastases.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
1秒前
2秒前
3秒前
3秒前
善学以致用应助薛华倩采纳,获得10
5秒前
huqingtao完成签到,获得积分10
5秒前
了了完成签到,获得积分10
5秒前
6秒前
6秒前
666完成签到,获得积分10
7秒前
10秒前
11秒前
星辰大海应助樱桃窝窝头采纳,获得10
12秒前
258369完成签到,获得积分10
13秒前
14秒前
15秒前
Sunwenrui发布了新的文献求助10
16秒前
薛华倩发布了新的文献求助10
20秒前
白白SAMA123发布了新的文献求助10
20秒前
20秒前
昏睡的飞机完成签到,获得积分10
20秒前
21秒前
22秒前
24秒前
miaojuly发布了新的文献求助10
24秒前
共享精神应助追寻筮采纳,获得10
24秒前
25秒前
莫歌完成签到 ,获得积分10
25秒前
2889580752发布了新的文献求助10
26秒前
量子星尘发布了新的文献求助10
26秒前
杨冠文发布了新的文献求助10
26秒前
HOME发布了新的文献求助10
28秒前
liz_应助努力工作的人采纳,获得10
29秒前
Lycerdoctor发布了新的文献求助10
29秒前
东瓜魔法师完成签到,获得积分10
29秒前
杨冠文完成签到,获得积分10
31秒前
31秒前
Owen应助肖肖采纳,获得10
32秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035