Dynamic Eye Closure Restoration in Facial Palsy with Neurotized Platysma Muscle Graft in Rats

医学 眼睑 眼轮匝肌 面神经 角膜反射 麻痹 反射 外科 面瘫 颅神经疾病 解剖 麻醉 眼病 替代医学 病理
作者
Tsz Yin Voravitvet,Yenlin Huang,Sawarin Voravitvet,Juan Larsson,Po‐Hao Lien,David Chwei‐Chin Chuang,Johnny Chuieng-Yi Lu,Tommy Nai‐Jen Chang
出处
期刊:Journal of Reconstructive Microsurgery [Thieme Medical Publishers (Germany)]
标识
DOI:10.1055/s-0044-1788565
摘要

Abstract Background One of the most devastating deficits of facial paralysis is eyelid dysfunction, which is controlled by the orbicularis oculi muscle (OOM), as it leads to loss of the protective mechanism of the eye. This study used a rat model to assess the functional outcomes of neurotized platysma muscle grafts (PMGs) for OOM replacement. Methods Forty male Sprague-Dawley rats with iatrogenic right eyelid dysfunction were divided into five groups: one control group and four groups utilizing PMG with different sources of nerve innervation. Eyelid function recovery was assessed at 2, 4, 6, and 8 weeks. The PMGs were harvested for pathological examination at the end of the study. Results All rats except those in the control group and one from the group using ipsilateral frontal and upper zygomatic frontal nerve branches directly neurotized to the PMG (nerve-to-muscle) recovered eyelid closure function within 8 weeks of the study period. The mean recovery time was 3.87 ± 1.28 weeks. A total of 87.5% of rats that had the contralateral zygomatic branch as the donor nerve regained the consensual corneal reflex (p-value < 0.001). Conclusion Replacement of neurotized PMG for OOM function is successful in a rat model. Using the upper zygomatic branch as the donor nerve, it was possible to restore the consensual corneal reflex. This method shows promise for further human studies.
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