生物
丁香假单胞菌
拟南芥
免疫活性
免疫系统
植物免疫
微生物群
拟南芥
微生物学
免疫
病菌
免疫学
遗传学
基因
突变体
作者
Bradley C. Paasch,Reza Sohrabi,James M. Kremer,Kinya Nomura,Yu Ti Cheng,Jennifer Martz,Brian H. Kvitko,James M. Tiedje,Sheng Yang He
出处
期刊:Nature plants
[Springer Nature]
日期:2023-08-17
卷期号:9 (9): 1468-1480
被引量:10
标识
DOI:10.1038/s41477-023-01501-1
摘要
Although many studies have shown that microbes can ectopically stimulate or suppress plant immune responses, the fundamental question of whether the entire preexisting microbiota is indeed required for proper development of plant immune response remains unanswered. Using a recently developed peat-based gnotobiotic plant growth system, we found that Arabidopsis grown in the absence of a natural microbiota lacked age-dependent maturation of plant immune response and were defective in several aspects of pattern-triggered immunity. Axenic plants exhibited hypersusceptibility to infection by the bacterial pathogen Pseudomonas syringae pv. tomato DC3000 and the fungal pathogen Botrytis cinerea. Microbiota-mediated immunocompetence was suppressed by rich nutrient conditions, indicating a tripartite interaction between the host, microbiota and abiotic environment. A synthetic microbiota composed of 48 culturable bacterial strains from the leaf endosphere of healthy Arabidopsis plants was able to substantially restore immunocompetence similar to plants inoculated with a soil-derived community. In contrast, a 52-member dysbiotic synthetic leaf microbiota overstimulated the immune transcriptome. Together, these results provide evidence for a causal role of a eubiotic microbiota in gating proper immunocompetence and age-dependent immunity in plants.
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