脊髓小脑共济失调
视网膜
神经纤维层
眼科
青光眼
视盘
医学
眼压
病理
疾病
作者
Flávio Moura Rezende Filho,Neringa Jurkutė,João Brainer Clares de Andrade,Bruna Ferraço Marianelli,Fabrício Diniz de Lima,Marcondes C. França,Juliana Maria Ferraz Sallum,Patrick Yu‐Wai‐Man,Orlando Graziani Póvoas Barsottini,José Luiz Pedroso
摘要
ATXN2 is the causative gene of spinocerebellar ataxia type 2 (SCA2) and has been implicated in glaucoma pathogenesis. Therefore, studying ocular changes in SCA2 could uncover clinically relevant changes.The aim was to investigate optic disc and retinal architecture in SCA2.We evaluated 14 patients with SCA2 and 26 controls who underwent intraocular pressure measurement, fundoscopy, and macular and peripapillary spectral domain optical coherence tomography (SD-OCT). We compared SD-OCT measurements in SCA2 and controls, and the frequency of glaucomatous changes among SCA2, controls, and 76 patients with other SCAs (types 1, 3, 6, and 7).The macula, peripapillary retinal nerve fiber and inner plexiform layers were thinner in SCA2 than in controls. Increased cup-to-disc ratio was more frequent in SCA2 than in controls and other SCAs.Ocular changes are part of SCA2 phenotype. Future studies should further investigate retinal and optic nerve architecture in this disorder. © 2023 International Parkinson and Movement Disorder Society.
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