哌嗪
醋酸
外消旋化
化学
对映体
有机化学
组合化学
作者
Srinivas Chamakuri,Sunny Ann Tang,Kevin Tran,Shiva Krishna Reddy Guduru,Peter K. Bolin,Kevin R. MacKenzie,Damian W. Young
出处
期刊:Molecules
[MDPI AG]
日期:2022-05-25
卷期号:27 (11): 3419-3419
被引量:2
标识
DOI:10.3390/molecules27113419
摘要
We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five steps with a high enantiomeric purity. The novel route facilitated, for the first time, the synthesis of 3-phenyl substituted-2-piperazine acetic acid esters that were difficult to achieve using other methods; however, in this case, the products underwent racemization.
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