Retinoblastoma

Retinoblastoma (Rb) is the most common malignant intra-ocular tumour in childhood, with an incidence of 1/15 000–20 000 births. Two-thirds of these tumours are unilateral, mostly non hereditary, with a median age of 2 years at diagnosis. One third are hereditary and bilateral, with a median age of 1 year at diagnosis[ 1 Donaldson S, Egbert PR, Newsham I, Cavenee WK. Retinoblastoma. In Pizzo PA, Poplack DG, eds. Principles and practice of pediatric oncology, 3rd edn. Philadelphia, JB Lippincott, 1997, 699–716. Google Scholar ].