Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

材料科学 再生医学 组织工程 生物医学工程 纳米技术 脚手架 生物相容性 医学 干细胞 遗传学 冶金 生物
作者
Drake D. Pedersen,Seungil Kim,William R. Wagner
出处
期刊:Journal of Biomedical Materials Research Part A [Wiley]
卷期号:110 (8): 1460-1487 被引量:34
标识
DOI:10.1002/jbm.a.37394
摘要

Abstract Early explorations of tissue engineering and regenerative medicine concepts commonly utilized simple polyesters such as polyglycolide, polylactide, and their copolymers as scaffolds. These biomaterials were deemed clinically acceptable, readily accessible, and provided processability and a generally known biological response. With experience and refinement of approaches, greater control of material properties and integrated bioactivity has received emphasis and a broadened palette of synthetic biomaterials has been employed. Biodegradable polyurethanes (PUs) have emerged as an attractive option for synthetic scaffolds in a variety of tissue applications because of their flexibility in molecular design and ability to fulfill mechanical property objectives, particularly in soft tissue applications. Biodegradable PUs are highly customizable based on their composition and processability to impart tailored mechanical and degradation behavior. Additionally, bioactive agents can be readily incorporated into these scaffolds to drive a desired biological response. Enthusiasm for biodegradable PU scaffolds has soared in recent years, leading to rapid growth in the literature documenting novel PU chemistries, scaffold designs, mechanical properties, and aspects of biocompatibility. Despite the enthusiasm in the field, there are still few examples of biodegradable PU scaffolds that have achieved regulatory approval and routine clinical use. However, there is a growing literature where biodegradable PU scaffolds are being specifically developed for a wide range of pathologies and where relevant pre‐clinical models are being employed. The purpose of this review is first to highlight examples of clinically used biodegradable PU scaffolds, and then to summarize the growing body of reports on pre‐clinical applications of biodegradable PU scaffolds.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李爱国应助郝宝真采纳,获得10
1秒前
Amor完成签到,获得积分10
1秒前
1秒前
完美世界应助小鬼采纳,获得10
2秒前
3秒前
苍山洱海旁完成签到 ,获得积分10
4秒前
星辰大海应助科研通管家采纳,获得10
5秒前
JamesPei应助科研通管家采纳,获得10
5秒前
传奇3应助科研通管家采纳,获得30
5秒前
我是老大应助科研通管家采纳,获得10
5秒前
丘比特应助科研通管家采纳,获得10
5秒前
zhikaiyici应助科研通管家采纳,获得10
5秒前
完美世界应助科研通管家采纳,获得10
5秒前
桐桐应助科研通管家采纳,获得200
5秒前
科研通AI2S应助科研通管家采纳,获得10
5秒前
5秒前
梧桐的灯完成签到,获得积分10
10秒前
真龙狂婿完成签到,获得积分10
11秒前
13秒前
跟屁虫完成签到,获得积分10
15秒前
16秒前
可口可乐发布了新的文献求助10
16秒前
春夏爱科研完成签到,获得积分10
17秒前
屁颠屁颠_狼完成签到 ,获得积分0
18秒前
DCW完成签到 ,获得积分10
18秒前
18秒前
嘻嘻印完成签到,获得积分10
19秒前
iWatchTheMoon应助mokosk采纳,获得10
20秒前
小聪发布了新的文献求助10
21秒前
23秒前
25秒前
科目三应助鲁滨逊采纳,获得10
26秒前
NPC-CBI完成签到,获得积分10
27秒前
雨木目完成签到,获得积分10
27秒前
杨乃彬完成签到,获得积分10
28秒前
小聪完成签到,获得积分10
30秒前
huhu完成签到,获得积分10
30秒前
HR112发布了新的文献求助20
30秒前
小鬼发布了新的文献求助10
30秒前
乐乐应助芳凤凤凤iona采纳,获得30
31秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3163007
求助须知:如何正确求助?哪些是违规求助? 2813990
关于积分的说明 7902812
捐赠科研通 2473633
什么是DOI,文献DOI怎么找? 1316952
科研通“疑难数据库(出版商)”最低求助积分说明 631560
版权声明 602187