材料科学
灭菌(经济)
杰纳斯
光热治疗
纳米纤维
膜
纳米技术
排水
化学工程
生物医学工程
医学
生态学
工程类
生物
货币经济学
经济
外汇市场
遗传学
外汇
作者
Xiaojing Zhang,Nuo Yu,Qian Ren,Shining Niu,Liqiong Zhu,Ling Hong,Kemi Cui,Xiao Wang,Weizhong Jiang,Mei Wen,Zhigang Chen
标识
DOI:10.1002/adfm.202315020
摘要
Abstract Diabetic wounds are difficult to heal, and the key to wound healing is exudate management and effective disinfection. Inspired by the asymmetric wettability of Janus‐structured lotus leaves, herein the study has presented the design of a biomimetic asymmetric Janus membrane that integrates unidirectional biofluid drainage and photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic wound healing. This Janus membrane is prepared by electrospinning polyacrylonitrile (PAN) nanofiber membrane containing polydopamine (PDA) on the surface of polypropylene (PP) nonwoven membrane. Such PP/PAN x%PDA Janus membrane enables antigravity “pumping” of the water from the hydrophobic PP layer to the hydrophilic PAN x%PDA layer within 22 s through contact points on the Janus interface. The incorporation of 30 wt% PDA in PAN imparts high photoabsorption and photothermal responsiveness, facilitating continuous volatilization of the exudate, achieving twice the displacement of water, and causing irreversible damage to bacteria. As a result, it effectively alleviates inflammation and cellular fibrosis while promoting collagen deposition due to its structure and antibacterial properties. Impressively, such photothermal‐enhanced Janus membrane achieves an impressive closure rate of 96.7% for diabetic wounds, better than that of (59.8%) for conventional bandages. Therefore, this asymmetric Janus membrane offers a promising alternative for the healing of chronic diabetic wounds.
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