Effect of Body Mass Index on Effectiveness of CT versus Invasive Coronary Angiography in Stable Chest Pain: The DISCHARGE Trial

医学 狼牙棒 胸痛 冠状动脉疾病 危险系数 临床终点 放射科 体质指数 心脏病学 冲程(发动机) 前瞻性队列研究 内科学 随机对照试验 置信区间 心肌梗塞 经皮冠状动脉介入治疗 机械工程 工程类
作者
Robert Sykes,Damien Collison,Béla Merkely,Klaus F. Kofoed,Patrick Donnelly,José F. Rodríguez‐Palomares,Andrejs Ērglis,Josef Veselka,Gintarė Šakalytė,Nada Čemerlić Ađić,Matthias Gutberlet,Jonathan D. Dodd,Ignacio Diez,Gershan Davis,Elke Zimmermann,Cezary Kępka,Radosav Vidaković,Marco Francone,Małgorzata Ilnicka-Suckiel,Fabian Plank,Juhani Knuuti,Rita Faria,Stephen Schröder,Colin Berry,Luca Saba,Balázs Ruzsics,Nina Rieckmann,Christine Kubiak,Kristian Schultz Hansen,Jacqueline Müller‐Nordhorn,Pál Maurovich‐Horvat,Andreas Dehlbæk Knudsen,Imre Benedek,Clare Orr,Filipa Valente,Ligita Zvaigzne,Martin Horváth,Antanas Jankauskas,Filip Ađić,Michael Woinke,Stephen Keane,Iñigo Lecumberri,Erica Thwaite,Michael Laule,Mariusz Kruk,Aleksandra Zivanic,Massimo Mancone,Donata Kuśmierz,Gudrun Feuchtner,Mikko Pietilä,Vasco Gama Ribeiro,Tanja Drosch,Christian Delles,Michele Porcu,Michael Fisher,Tamás Bárány,Charlotte Sørum,Rosca Aurelian,Stephanie Kelly,Bruno García del Blanco,Ainhoa Rubio,Bálint Szilveszter,Jawdat Abdulla,Ioana Rodean,Susan Regan,Hug Cuéllar,Milán Vecsey-Nagy,Birgit Jurlander,Roxana Hodaș,Sarah Feger,Mahmoud Mohamed,Lina María Serna‐Higuita,Konrad Neumann,Henryk Dreger,Matthias Rief,Viktoria Wieske,Maros Ferencik,Melanie Estrella,Maria Bosserdt,Peter Martus,Theodora Benedek,Marc Dewey
出处
期刊:Radiology [Radiological Society of North America]
卷期号:310 (2)
标识
DOI:10.1148/radiol.230591
摘要

Background Recent trials support the role of cardiac CT in the evaluation of symptomatic patients suspected of having coronary artery disease (CAD); however, body mass index (BMI) has been reported to negatively impact CT image quality. Purpose To compare initial use of CT versus invasive coronary angiography (ICA) on clinical outcomes in patients with stable chest pain stratified by BMI category. Materials and Methods This prospective study represents a prespecified BMI subgroup analysis of the multicenter Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial conducted between October 2015 and April 2019. Adult patients with stable chest pain and a CAD pretest probability of 10%–60% were randomly assigned to undergo initial CT or ICA. The primary end point was major adverse cardiovascular events (MACE), including cardiovascular death, nonfatal myocardial infarction, or stroke. The secondary end point was an expanded MACE composite, including transient ischemic attack, and major procedure-related complications. Competing risk analyses were performed using the Fine and Gray subdistribution Cox proportional hazard model to assess the impact of the relationship between BMI and initial management with CT or ICA on the study outcomes, whereas noncardiovascular death and unknown causes of death were considered competing risk events. Results Among the 3457 participants included, 831 (24.0%), 1358 (39.3%), and 1268 (36.7%) had a BMI of less than 25, between 25 and 30, and greater than 30 kg/m2, respectively. No interaction was found between CT or ICA and BMI for MACE (P = .29), the expanded MACE composite (P = .38), or major procedure-related complications (P = .49). Across all BMI subgroups, expanded MACE composite events (CT, 10 of 409 [2.4%] to 23 of 697 [3.3%]; ICA, 26 of 661 [3.9%] to 21 of 422 [5.1%]) and major procedure-related complications during initial management (CT, one of 638 [0.2%] to five of 697 [0.7%]; ICA, nine of 630 [1.4%] to 12 of 422 [2.9%]) were less frequent in the CT versus ICA group. Participants with a BMI exceeding 30 kg/m² exhibited a higher nondiagnostic CT rate (7.1%, P = .044) compared to participants with lower BMI. Conclusion There was no evidence of a difference in outcomes between CT and ICA across the three BMI subgroups. Clinical trial registration no. NCT02400229 © RSNA, 2024 Supplemental material is available for this article.
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