[Genome sequence analysis of two SARS-CoV-2 virus infections in Inner Mongolia, 2022].

The target gene sequences of the novel coronaviruses obtained by sequencing were compared with the reference sequences to analyze the genetic variation of the two cases of the novel coronaviruses from Inner Mongolia Autonomous Region in 2022 and to explore the sources of infection. The results showed that the two sequences belonged to different evolutionary branches, Delta (AY.122) and Omicron (BA.1.1), respectively. hCoV-19/Inner Mongolia/IVDC-591/2022 had 48 single nucleotide polymorphisms on the genome sequences, sharing 40 nucleotide mutation sites with a Mongolian strain; hCoV-19/Inner Mongolia/IVDC-592/2022 genome shared 57 nucleotide mutation sites with a UK strain, and the nucleotide mutation site identity was 100% (57/57). Phylogenetic analysis showed that the target gene sequences were not directly related to domestic novel coronavirus sequences during the same period, but were related to isolates from Europe and Mongolia.通过测序获得的新型冠状病毒目标基因序列与参考序列进行比对，分析内蒙古自治区的两例新型冠状病毒的基因变异情况并探索其感染来源。结果显示，两条序列分别属于不同的进化分支，Delta（AY.122）和Omicron（BA.1.1），hCoV-19/Inner Mongolia/IVDC-591/2022基因组序列上共有48个单核苷酸多态性，与一株蒙古国毒株共享40个核苷酸突变位点；hCoV-19/Inner Mongolia/IVDC-592/2022基因组与一株英国毒株共享57个核苷酸突变位点，核苷酸突变位点一致性为 100%（57/57）。系统发育分析表明，目标基因序列与同期国内新型冠状病毒序列间并无直接关联，而与欧洲、蒙古国的分离株存在关联。.