Strategic nanocarriers to control neurodegenerative disorders: Concept, challenges, and future perspective

纳米载体 医学 纳米医学 植物医学 药物输送 临床试验 重症监护医学 药品 药理学 纳米技术 病理 纳米颗粒 材料科学 免疫学
作者
Sumel Ashique,Obaid Afzal,Sabina Yasmin,Afzal Hussain,Mohammad A. Altamimi,Thomas J. Webster,Abdulmalik Saleh Alfawaz Altamimi
出处
期刊:International Journal of Pharmaceutics [Elsevier]
卷期号:633: 122614-122614 被引量:10
标识
DOI:10.1016/j.ijpharm.2023.122614
摘要

Various neurodegenerative diseases (parkinson, huntington, alzheimer, and amyotrophic lateral sclerosis) are becoming serious global health challenges. Despite various treatment options, successful delivery and effective outcomes have been challenged with several physiological-anatomical barriers, formulation related issues, post-administration hurdles, regulatory constraints, physical hurdles, environmental issues, and safety concern. In the present review, we addressed a brief understanding of pathological and normal condition of blood brain barrier (BBB), rational for brain delivery using nanocarriers, major challenges, advantages of nanomedicine, critical aspects of nanomedicine to translate from bed to clinics, and strategic approaches for improved delivery across BBB. The review addressed various mechanistic perspective for delivery of drug loaded nanocarriers across BBB. Moreover, several reports have been published wherein phytomedicine, exosomes, magnetic nanopartilces, functionalized nanocarriers, cationic nanopartilces, and nano-phytomedicine were investigated for remarkable improvement in neurological disorders. These findings are informative for healthcare professionals, researchers, and scientists working in the domains. The successful application and convincing outcomes of nanomedicines were envisaged with clinical trials conducted on various drugs intended to control neurological disorders (NDs). Conclusively, the review addressed comprehensive findings on various aspects of drug loaded nanocarrier delivery across BBB, considerable risks, potential therapeutic benefits, clinical trial based outcomes, and recent advances followed by future perspectives.
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