A Review on Piezoelectric-mediated Mechanoredox Reactions by Ball Milling in Organic Synthesis

Abstract: Recently, the concept of mechanoredox chemistry has been proposed and welldeveloped in organic synthesis. Mechanoredox chemistry is conceptually similar to a photocatalyst reaction system, where piezoelectric materials are introduced to the reaction system in a manner analogous to photoredox catalysis. These reactions feature the ability to generate high-value radicals that do not require harsh reaction conditions of anhydrous and anaerobic conditions, an expensive photocatalyst, and the use of solvents, which renders these transformations highly industrially applicable. In addition, mechanoredox chemistry is also an emerging interdisciplinary research field that combines material chemistry with synthetic chemistry to create more useful reactions. This review provides a comprehensive summary of progress to date in the specific transformation and related mechanisms of piezoelectric- mediated mechanoredox reactions by ball milling in organic synthesis.