脂毒性
不育
肥胖
男性不育
脂肪因子
繁殖
生殖健康
代谢综合征
医学
生理学
激素
生殖医学
生物
妇科
内分泌学
瘦素
怀孕
环境卫生
胰岛素抵抗
生态学
人口
遗传学
作者
Melody A. Rasouli,Daniel A. Dumesic,Vibha Singhal
出处
期刊:Current Opinion in Endocrinology, Diabetes and Obesity
[Ovid Technologies (Wolters Kluwer)]
日期:2024-09-10
标识
DOI:10.1097/med.0000000000000883
摘要
Purpose of review The increasing rate of obesity is having an adverse impact on male reproduction. Recent findings The negative effect of reactive oxygen species on male reproductive tissues and the age of onset of obesity are new areas of research on male infertility. Summary This review highlights how obesity impairs male reproduction through complex mechanisms, including metabolic syndrome, lipotoxicity, sexual dysfunction, hormonal and adipokine alterations as well as epigenetic changes, and how new management strategies may improve the reproductive health of men throughout life.
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