聚砜
膜
聚乙烯吡咯烷酮
材料科学
高分子化学
化学工程
蛋白质吸附
吸附
聚合物
化学
有机化学
复合材料
生物化学
工程类
作者
Akon Higuchi,Kazunobu Shirano,Masaharu Harashima,Boo Ok Yoon,Mariko Hara,Mitsuo Hattori,Kazuo Imamura
出处
期刊:Biomaterials
[Elsevier]
日期:2002-07-01
卷期号:23 (13): 2659-2666
被引量:232
标识
DOI:10.1016/s0142-9612(01)00406-9
摘要
Hydrophilic polysulfone membranes (PVP-PSf) were prepared from polysulfone membranes covalently conjugated with polyvinylpyrrolidone (PVP) on the surface. The immobilized amount of vinylpyrrolidone on PVP-PSf membranes was controlled by the amount of vinylpyrrolidone monomer in the reaction solution and the reaction time. The PVP-PSf membranes were found to be the most hydrophilic membranes among the polysulfone and surface-modified polysulfone membranes prepared in this study. This is explained by the long hydrophilic side chain of polyvinylpyrrolidone on the PVP-PSf membranes which contributes to the hydrophilic wiper on the hydrophobic PSf membranes. It was found that PVP-PSf membranes gave lower protein adsorption from a plasma solution than polysulfone and other surface-modified membranes (p < 0.01). This is attributed to the hydrophilic surface of the PVP-PSf membranes, because the hydrophilic surface is known to reduce the protein adsorption on the membranes. The PVP-PSf membranes showed a much suppressed number of adhering platelets on the surface than polysulfone and other surface-modified membranes (p < 0.01). It is suggested that the hydrophilic surface of the PVP-PSf membranes without ionic groups causes the suppression of platelet adhesion on the PVP-PSf membranes and that the long hydrophilic side chain of polyvinylpyrrolidone on PVP-PSf membranes contributes to the hydrophilic and hemocompatible wipers on the surface of the hydrophobic PSf membranes.
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