催化作用
化学
组合化学
药物化学
立体化学
有机化学
作者
Amit Kumar Simlandy,Mao‐Yun Lyu,M. Kevin Brown
出处
期刊:ACS Catalysis
日期:2021-10-06
卷期号:11 (20): 12815-12820
被引量:28
标识
DOI:10.1021/acscatal.1c03491
摘要
A method to achieve the synthesis of highly substituted spirocyclic cyclobutanes is disclosed. The reaction involves the catalytic arylboration of cyclobutenes. Depending on the substitution pattern of the cyclobutene, either a Cu/Pd- or a Ni-catalyzed reaction was utilized. In the case of the Cu/Pd catalyzed reactions, the identification of a Cu-complex for arylboration was crucial to observe high selectivity. The synthetic utility of the products is demonstrated, and the mechanistic details are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI