Water-Resistant, Scalable, and Inexpensive Chiral Metal–Organic Framework Featuring Global Negative Electrostatic Potentials for Efficient Acetylene Separation

Physical separation of acetylene (C2H2) from carbon dioxide (CO2) or ethylene (C2H4) on metal-organic frameworks (MOFs) is crucial for achieving high-purity feed gases with minimal energy penalty. However, such processes are exceptionally challenging due to their close physical properties and are also critically restricted by the high cost of large-scale MOF synthesis. Here, we demonstrate the readily scalable synthesis of a highly water-resistant chiral Cu-MOF (TAMOF-1) based on an inexpensive proteogenic amino acid derivative bearing rich N/O sites. Notably, the unique coordination in this ultramicroporous MOF has resulted in the generation of rare global negative electrostatic potentials, which greatly facilitate the electrostatic interactions with C2H2 molecules, thus leading to their efficient separation from C2H2/CO2 and C2H2/C2H4 mixtures under ambient conditions. The separation efficiency and mechanism are unequivocally validated by breakthrough experiments and computational simulations. This work not only highlights the pivotal role of creating a negative electro-environment in confined spaces for boosting C2H2 capture and separation but also opens up new ways of employing cheap amino acid derivatives bearing rich electro-negative N and O sites as organic linkers to constructing high-performing MOF materials for gas separation purposes.