基质金属蛋白酶
细胞外基质
基底膜
转移
食管癌
血管生成
癌症研究
基质金属蛋白酶抑制剂
癌变
癌症
腺癌
病理
医学
生物
内科学
细胞生物学
作者
Magdalena Groblewska,Maria Siewko,Barbara Mroczko,Maciej Szmitkowski
标识
DOI:10.5603/fhc.2012.0002
摘要
Esophageal cancer (EC) is one of the most aggressive malignant tumors of the gastrointestinal tract. There are two distinct histological types of EC: esophageal squamous cell carcinoma and adenocarcinoma of the esophagus. Etiologic factors and the patterns of incidence of both subtypes are different. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in esophageal carcinogenesis. Gellatinases MMP-2 and MMP-9 are able to degrade collagen IV from basement membranes and extracellular matrix which is related to tumor progression, including invasion, metastasis, growth and angiogenesis. It has been shown that increased expression of MMPs plays a crucial role in the development of several human malignancies, including esophageal cancer. The activity of MMPs is regulated by their endogenous natural inhibitors (TIMPs). Among these, the roles of TIMP-1 and TIMP-2 in EC development, tumor progression and formation of metastases have been most extensively characterized and best recognized.
科研通智能强力驱动
Strongly Powered by AbleSci AI