经颅交流电刺激
心理学
神经心理学
脑电图
随机对照试验
辅助电机区
听力学
帕金森病
物理医学与康复
认知
医学
神经科学
磁刺激
刺激
功能磁共振成像
内科学
疾病
作者
Alessandra Del Felice,Leonora Castiglia,Emanuela Formaggio,Manuela Cattelan,Bruno Scarpa,Paolo Manganotti,Elena Tenconi,Stefano Masiero
标识
DOI:10.1016/j.clinph.2019.04.601
摘要
Abnormal cortical oscillations are markers of Parkinson’s Disease (PD). Transcranial alternating current stimulation (tACS) can modulate brain oscillations and possibly impact on behaviour. Mapping of cortical activity (prevalent oscillatory frequency and topographic scalp distribution) may provide a personalized neurotherapeutic target and guide non-invasive brain stimulation. This is a cross-over, double blinded, randomized trial. Electroencephalogram (EEG) from participants with PD were recorded. TACS frequency/site were individually defined based on statistical comparison of EEG power spectra maps with normative data from our laboratory. Participants were randomized to tACS or random noise stimulation (RNS), 5 days/week for 2-weeks followed by ad hoc physical therapy. EEG, motor (Unified Parkinson’s Disease Rating Scale-motor: UPDRS III), neuropsychological (frontal, executive and memory tests) performance and mood were measured before (T0), after (T1) and 4-weeks after treatment (T2). A linear model with random effects and Wilcoxon test were used to detect differences. Main results include a reduction of beta rhythm in theta-tACS vs. RNS group at T1 over right sensorimotor area (p = 0.014) and left parietal area (p = 0.010) and at T2 over right sensorimotor area (p = 0.004) and left frontal area (p = 0.039). Bradykinesia items improved at T1 (p = 0.002) and T2 (p = 0.047) compared to T0 in the tACS group. In the tACS group the Montréal Cognitive Assessment (MoCA) improved at T2 compared with T1 (p = 0.049). Individualized tACS in PD improves motor and cognitive performance. These changes are associated with a reduction of excessive fast oscillations.
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