自愈水凝胶
小分子
分子
组合化学
材料科学
纳米技术
生物降解
化学
高分子化学
有机化学
生物化学
作者
Haotian Li,Jianhua Zhang,Hongrui Xue,Lin Li,Xun Liu,Lei Yang,Zhipeng Gu,Yiyun Cheng,Yiwen Li,Quan Huang
出处
期刊:Materials horizons
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:10 (5): 1789-1794
被引量:17
摘要
All-small-molecule dynamic hydrogels have shown great promise in cell culture, tissue engineering, and controlled drug release. The further development of more kinds of all-small-molecule dynamic hydrogels is severely hindered by the lack of enough commensurate building blocks from nature and on the market. Inspired by the widely developed metal-organic framework structures, herein we report a facile fabrication of metallogels by direct gelation of small molecular compounds including aminoglycosides (AGs), 2,2'-bipyridine-4,4'-dicarboxaldehyde (BIPY), and metal ions via coordination interactions and Schiff base reactions. These prepared metallogels exhibited good biodegradability and biosafety, excellent conductivity, tunable mechanical properties and potent antibacterial activities both in vitro and in vivo. This study provides a new strategy for expanding the scope of all-small-molecule dynamic metallogels for various biomedical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI