Dissecting the causal role of early inferior frontal activation in reading

缘上回 心理学 脑磁图 额下回 磁刺激 认知心理学 离解(化学) 阅读(过程) 认知 启动(农业) 演讲制作 听力学 功能磁共振成像 神经科学 刺激 脑电图 语言学 语音识别 计算机科学 医学 哲学 化学 发芽 植物 物理化学 生物
作者
Tomoki Uno,Kouji Takano,Kimihiro Nakamura
出处
期刊:The Journal of Neuroscience [Society for Neuroscience]
卷期号:: e0194242024-e0194242024
标识
DOI:10.1523/jneurosci.0194-24.2024
摘要

Cognitive models of reading assume that speech production occurs after visual and phonological processing of written words. This traditional view is at odds with more recent magnetoencephalography studies showing that the left posterior inferior frontal cortex (pIFC) classically associated with spoken production responds to print at 100-150 ms after word-onset, almost simultaneously with posterior brain regions for visual and phonological processing. Yet the theoretical significance of this fast neural response remains open to date. We used transcranial magnetic stimulation (TMS) to investigate how the left pIFC contributes to the early stage of reading. In Experiment 1, 23 adult participants (14 females) performed three different tasks about written words (oral reading, semantic judgment and perceptual judgment) while single-pulse TMS was delivered to the left pIFC, fusiform gyrus or supramarginal gyrus at different time points (50 to 200 ms after word-onset). A robust double dissociation was found between tasks and stimulation sites - oral reading, but not other control tasks, was disrupted only when TMS was delivered to pIFC at 100 ms. This task-specific impact of pIFC stimulation was further corroborated in Experiment 2, which revealed another double dissociation between oral reading and picture naming. These results demonstrate that the left pIFC specifically and causally mediates rapid computation of speech motor codes at the earliest stage of reading and suggest that this fast sublexical neural pathway for pronunciation, although seemingly dormant, is fully functioning in literate adults. Our results further suggest that these left-hemisphere systems for reading overall act faster than known previously.
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