减数分裂
卵母细胞
细胞生物学
包络线(雷达)
生物
化学
生物物理学
遗传学
物理
计算机科学
电信
胚胎
基因
雷达
作者
Chenshu Liu,Abby F. Dernburg
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-11-21
卷期号:386 (6724)
标识
DOI:10.1126/science.adm7969
摘要
Sexual reproduction relies on robust quality control during meiosis. Assembly of the synaptonemal complex between homologous chromosomes (synapsis) regulates meiotic recombination and is crucial for accurate chromosome segregation in most eukaryotes. Synapsis defects can trigger cell cycle delays and, in some cases, apoptosis. We developed and deployed a chemically induced proximity system to identify key elements of this quality control pathway in Caenorhabditis elegans . Persistence of the polo-like kinase PLK-2 at pairing centers—specialized chromosome regions that interact with the nuclear envelope—induced apoptosis of oocytes in response to phosphorylation and destabilization of the nuclear lamina. Unexpectedly, the Piezo1/PEZO-1 channel localized to the nuclear envelope and was required to transduce this signal to promote apoptosis in maturing oocytes.
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