骨整合
材料科学
药物输送
纳米管
生物医学工程
阳极氧化
间充质干细胞
纳米技术
钛
体内
植入
复合材料
碳纳米管
外科
医学
铝
冶金
生物技术
病理
生物
作者
Junqing Ma,Xiaoxu Xu,Xiao‐Tong Song,Leilei Hong,Zhongyin Zhang,Junqing Ma,Xiaoliang Wang
出处
期刊:Biomaterials advances
日期:2022-06-01
卷期号:137: 212853-212853
被引量:6
标识
DOI:10.1016/j.bioadv.2022.212853
摘要
Anodic titanium dioxide nanotubes (TNT) have a range of beneficial theranostic properties. However, a lack of effective osseointegration is a problem frequently associated with the titanium dental implant surface. Here, we investigated whether bone-shaped nanotube titanium implants could enhance osseointegration via promoting initial release of vascular endothelial growth factor 165 (VEGF165) and dual release of recombinant human bone morphogenetic protein-2 (rhBMP-2). Thus, we generated cylindrical-shaped nanotubes (TNT1) and bone-shaped nanotubes (TNT2) through voltage-varying and time-varying electrochemical anodization methods, respectively. Additionally, we prepared rhBMP-2-loaded cylindrical-shaped nanotubes/VEGF165-loaded hydrogel (TNT-F1) and rhBMP-2-loaded bone-shaped nanotubes/VEGF165-loaded hydrogel (TNT-F2) drug delivery systems. We evaluated the characteristics and release kinetics of the drug delivery systems, and then analyzed the cytocompatibility and osteogenic differentiation of these specimens with mesenchymal stem cells (MSCs) in vitro. Finally, we utilized a rat femur defect model to test the bone formation capacity of nanotube-hydrogel drug delivery system in vivo. Among these different nanotubes structures, the bone-shaped one was the optimum structure for growth factor release.
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