白杨素
槲皮素
细胞凋亡
MCF-7型
活力测定
细胞周期
细胞毒性
化学
癌细胞
细胞周期检查点
细胞生长
药理学
癌症研究
癌症
生物化学
生物
类黄酮
体外
内科学
医学
抗氧化剂
人体乳房
作者
Patrícia Severo Ramos,Christian Ferreira,Carlos Luan Alves Passos,Jerson L. Silva,Eliane Fialho
标识
DOI:10.1016/j.biopha.2024.117276
摘要
Pharmacological properties of flavonoids have been reported, with an anticancer role amongst them, however, its mechanisms are not fully elucidated. In this study, the activity of quercetin and chrysin towards MCF-7 and MDA-MB-231 breast cancer cells was investigated. Cellular viability was determined after treatment with the compounds in different concentrations for 24 h. Secondly, cells were treated with fixed concentration of chrysin and different concentrations of quercetin with preincubation for 1 h. Both compounds inhibited cellular proliferation in dose-dependent manner. The association showed improvement in their cytotoxicity, more expressively with preincubation of quercetin. Quercetin and chrysin association induced cell cycle arrest in sub-G0/G1 phase in MDA-MB-231 cells, modified the expression of caspases-3 and -8,-8, inducing late apoptosis cell death. Taken together, our results demonstrate that both flavonoids inhibited cells growth in a dose-dependent manner and the association of quercetin improved chrysin's toxic effect over the cell lines.
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