Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology

胚胎 人类受精 胚胎质量 精子 男科 生物标志物 体外受精 不育 生物 辅助生殖技术 妊娠率 怀孕 医学 细胞生物学 遗传学
作者
Aijie Xin,Xiaoxi Sun,Tian-ying Yang,Ying Chen,Guowu Chen,Yi-Si Sun,Zhichao Li,Xiaorong Shen,Yini Zhang,Wen He,Dan Zhou,Huijuan Shi
出处
期刊:Asian Journal of Andrology [Medknow Publications]
卷期号:24 (3): 260-260
标识
DOI:10.4103/aja2021111
摘要

Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies (ART). So far, the clinical evaluation of embryo quality depends on embryo morphology. However, the clinical pregnancy rate is still low. Therefore, new indicators are needed to further improve the evaluation of embryo quality. Several studies have shown that the decrease of sperm-specific protein actin-like 7A (ACTL7A) leaded to low fertilization rate, poor embryo development, and even infertility. The aim of this study was to study whether the different expression levels of ACTL7A on sperm can be used as a biomarker for predicting embryo quality. In this study, excluding the factors of severe female infertility, a total of 281 sperm samples were collected to compare the ACTL7A expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization (IVF) laboratory outcomes. Our results indicated that the ACTL7A levels were significantly reduced in sperm samples presenting poor embryo quality. Furthermore, the protein levels showed a significant correlation with fertilization outcomes of ART. ACTL7A has the potential to be a biomarker for predicting success rate of fertilization and effective embryo and the possibility of embryo arrest. In conclusion, sperm-specific protein ACTL7A has a strong correlation with IVF laboratory outcomes and plays important roles in fertilization and embryo development.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
fyjlfy完成签到 ,获得积分10
4秒前
Vegeta完成签到 ,获得积分10
4秒前
laogao完成签到,获得积分10
5秒前
逃之姚姚完成签到 ,获得积分10
6秒前
辛勤香岚完成签到,获得积分10
7秒前
光亮书易完成签到,获得积分10
7秒前
10秒前
ccx完成签到,获得积分10
12秒前
Getlogger完成签到,获得积分10
15秒前
无私的以亦完成签到 ,获得积分10
17秒前
cheng完成签到 ,获得积分10
18秒前
wnll完成签到,获得积分10
20秒前
21秒前
小二郎应助irisjlj采纳,获得10
22秒前
jyhk完成签到,获得积分10
23秒前
马一一完成签到,获得积分10
25秒前
Gino完成签到,获得积分0
25秒前
JFP完成签到,获得积分10
25秒前
wnll发布了新的文献求助10
26秒前
29秒前
天天快乐应助dai采纳,获得10
29秒前
屹男完成签到 ,获得积分10
30秒前
Go完成签到,获得积分10
34秒前
36秒前
今后应助驼个文献采纳,获得10
38秒前
陶醉的烤鸡完成签到,获得积分10
39秒前
41秒前
wanci应助奇迹行者采纳,获得10
41秒前
dai完成签到,获得积分20
44秒前
罗明芳完成签到 ,获得积分10
47秒前
dai发布了新的文献求助10
48秒前
jackie完成签到,获得积分10
49秒前
49秒前
傅双庆完成签到,获得积分0
50秒前
细心书蕾完成签到 ,获得积分10
50秒前
JingP发布了新的文献求助10
52秒前
傅双庆发布了新的文献求助10
55秒前
vn完成签到,获得积分10
56秒前
壮壮发布了新的文献求助10
56秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
Introduction to Modern Controls, with illustrations in MATLAB and Python 310
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3056657
求助须知:如何正确求助?哪些是违规求助? 2713111
关于积分的说明 7434777
捐赠科研通 2358205
什么是DOI,文献DOI怎么找? 1249340
科研通“疑难数据库(出版商)”最低求助积分说明 607030
版权声明 596250