Sperm-specific protein ACTL7A as a biomarker for fertilization outcomes of assisted reproductive technology

胚胎 人类受精 胚胎质量 精子 男科 生物标志物 体外受精 不育 生物 辅助生殖技术 妊娠率 怀孕 医学 细胞生物学 遗传学
作者
Aijie Xin,Xiaoxi Sun,Tian-ying Yang,Ying Chen,Guowu Chen,Yi-Si Sun,Zhichao Li,Xiaorong Shen,Yini Zhang,Wen He,Dan Zhou,Huijuan Shi
出处
期刊:Asian Journal of Andrology [Medknow Publications]
卷期号:24 (3): 260-260
标识
DOI:10.4103/aja2021111
摘要

Obtaining high-quality embryos is one of the key factors to improve the clinical pregnancy rate of assisted reproductive technologies (ART). So far, the clinical evaluation of embryo quality depends on embryo morphology. However, the clinical pregnancy rate is still low. Therefore, new indicators are needed to further improve the evaluation of embryo quality. Several studies have shown that the decrease of sperm-specific protein actin-like 7A (ACTL7A) leaded to low fertilization rate, poor embryo development, and even infertility. The aim of this study was to study whether the different expression levels of ACTL7A on sperm can be used as a biomarker for predicting embryo quality. In this study, excluding the factors of severe female infertility, a total of 281 sperm samples were collected to compare the ACTL7A expression levels of sperms with high and low effective embryo rates and analyze the correlation between protein levels and in-vitro fertilization (IVF) laboratory outcomes. Our results indicated that the ACTL7A levels were significantly reduced in sperm samples presenting poor embryo quality. Furthermore, the protein levels showed a significant correlation with fertilization outcomes of ART. ACTL7A has the potential to be a biomarker for predicting success rate of fertilization and effective embryo and the possibility of embryo arrest. In conclusion, sperm-specific protein ACTL7A has a strong correlation with IVF laboratory outcomes and plays important roles in fertilization and embryo development.
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