载脂蛋白E
神经炎症
疾病
载脂蛋白B
淀粉样蛋白(真菌学)
神经科学
痴呆
阿尔茨海默病
病理生理学
医学
心理学
生物
内科学
病理
胆固醇
作者
Andrew B. Wolf,Jon Valla,Guojun Bu,Jungsu Kim,Mary Jo LaDu,Eric M. Reiman,Richard J. Caselli
摘要
APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer's disease. Current understanding of Alzheimer's disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas.
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