铁载体
生物合成
细菌
金黄色葡萄球菌
食腐动物
微生物学
广谱
生物化学
酶
化学
生物
螯合作用
组合化学
遗传学
抗氧化剂
无机化学
作者
Ghassan Ghssein,Catherine Brutesco,Laurent Ouerdane,Clémentine Fojcik,Amélie Izaute,Shuanglong Wang,Christine Hajjar,Ryszard Łobiński,David Lemaire,Pierre Richaud,Romé Voulhoux,Akbar Espaillat,Felipe Cava,David Pignol,Elise Borezée‐Durant,R. Haser
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-05-26
卷期号:352 (6289): 1105-1109
被引量:175
标识
DOI:10.1126/science.aaf1018
摘要
A new metal scavenger for bacteria All cells must find a way to acquire trace metals. Bacteria and plants scavenge iron, for instance, by synthesizing and releasing iron-chelating compounds called siderophores. Ghssein et al. describe three enzymes in Staphylococcus aureus that are responsible for the biosynthesis of another type of metallophore (see the Perspective by Nolan). Metabolomics and a range of biochemical assays show that this compound, named staphylopine, is involved in the uptake of a range of metals, depending on the growth environment. The genes required for staphylopine biosynthesis are conserved across a number of pathogenic bacteria and are similar to those for a broad-spectrum metallophore produced by plants. Science , this issue p. 1105 ; see also p. 1055
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