An indole diketopiperazine alkaloid and a bisabolane sesquiterpenoid with unprecedented skeletons from Aspergillus fumigatus

Fumitryprostatin A, an indole diketopiperazine alkaloid with a tricyclic 5/6/5 skeleton and fuminoid A, a sesquiterpenoid with a bicyclo[3.2.1]octane ring, were isolated Aspergillus fumigatus . Fumitryprostatin A exhibited moderate cytotoxic activity with an IC 50 of 14.6 μM.