体内
佐剂
细胞毒性T细胞
效应器
体外
免疫学
癌症研究
细胞
淋巴细胞
混合淋巴细胞反应
T细胞
生物
免疫系统
生物化学
生物技术
作者
James E. Talmadge,Barbara Lenz,Robin Pennington,Cedric W. Long,Hamblin Phillips,Mark Schneider,Henry R. Tribble
出处
期刊:PubMed
日期:1986-09-01
卷期号:46 (9): 4505-10
被引量:84
摘要
In this report, we describe the immunomodulatory properties and therapeutic efficacy of bestatin. Macrophage activation, but not natural killer cell augmentation, was observed both in vitro and in vivo. Immunostimulation of T-cell activity was observed in assays of allogeneic mixed lymphocyte response, but cytotoxic effector cells did not develop after an allogeneic mixed lymphocyte-tumor cell culture. Bestatin also had T-cell adjuvant activity when it was admixed with a suboptimal vaccine composed of irradiated tumor cells. We observed significant therapeutic activity against preexisting experimental and spontaneous metastases when bestatin was administered at high doses per animal for 4 weeks.
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