Precision Medicine Approaches to Cardiac Arrhythmias

医学 精密医学 重症监护医学 心脏病学 内科学 病理
作者
John R. Giudicessi,Michael J. Ackerman,Diane Fatkin,Jason C. Kovacic
出处
期刊:Journal of the American College of Cardiology [Elsevier]
卷期号:77 (20): 2573-2591 被引量:15
标识
DOI:10.1016/j.jacc.2021.03.325
摘要

In the initial 3 papers in this Focus Seminar series, the fundamentals and key concepts of precision medicine were reviewed, followed by a focus on precision medicine in the context of vascular disease and cardiomyopathy. For the remaining 2 papers, we focus on precision medicine in the context of arrhythmias. Specifically, in this fourth paper we focus on long QT syndrome, Brugada syndrome, and atrial fibrillation. The final (fifth) paper will deal with catecholaminergic polymorphic ventricular tachycardia. These arrhythmias represent a spectrum of disease ranging from common to relatively rare, with very different genetic and environmental causative factors, and with differing clinical manifestations that range from almost no consequences to lethality in childhood or adolescence if untreated. Accordingly, the emerging precision medicine approaches to these arrhythmias vary significantly, but several common themes include increased use of genetic testing, avoidance of triggers, and personalized risk stratification to guide the use of arrhythmia-specific therapies. • Diverse genetic and environmental factors may contribute to the genesis of cardiac arrhythmias. • Precision medicine approaches hold significant promise to enhance the diagnosis and treatment of potentially lethal cardiac arrhythmias. • Genetic testing, delineation of avoidable triggers, and risk stratification can be deployed to individualize specific antiarrhythmic therapies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
粗犷的书包完成签到,获得积分10
3秒前
4秒前
元素元枫发布了新的文献求助10
5秒前
6秒前
李健的小迷弟应助LYK888采纳,获得10
10秒前
11秒前
琪宝非宝完成签到,获得积分10
14秒前
真化石渡渡鸟完成签到,获得积分10
14秒前
小九不太乖举报Xxxxr求助涉嫌违规
15秒前
16秒前
慕青应助waitamoment采纳,获得10
17秒前
长安宁完成签到,获得积分10
17秒前
17秒前
典雅的俊驰完成签到,获得积分10
21秒前
LYK888发布了新的文献求助10
22秒前
22秒前
24秒前
25秒前
姜半兰完成签到,获得积分10
25秒前
华仔应助xtutang采纳,获得10
26秒前
顾矜应助漠悲漠痛采纳,获得10
29秒前
内向念双发布了新的文献求助10
30秒前
榴下晨光发布了新的文献求助10
33秒前
33秒前
34秒前
每文完成签到,获得积分10
34秒前
赘婿应助曾经的沧海采纳,获得10
34秒前
36秒前
37秒前
37秒前
眠羊完成签到,获得积分20
38秒前
Lucy__Kuo发布了新的文献求助10
39秒前
40秒前
41秒前
爆米花应助peikyang采纳,获得10
43秒前
小北笙er发布了新的文献求助10
43秒前
45秒前
源歌发布了新的文献求助10
45秒前
华仔应助hai采纳,获得10
46秒前
高分求助中
Sustainability in Tides Chemistry 2000
The ACS Guide to Scholarly Communication 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3076162
求助须知:如何正确求助?哪些是违规求助? 2729044
关于积分的说明 7507177
捐赠科研通 2377267
什么是DOI,文献DOI怎么找? 1260526
科研通“疑难数据库(出版商)”最低求助积分说明 611000
版权声明 597164