Nickel Hydride Catalyzed Remote Hydroarylation of Olefins

Abstract Metal hydride catalyzed remote hydrofunctionalization has attracted extensive attention in the past decade, as it provides a complementary approach for selective functionalization of remote C(sp3)–H bonds. Recently, a wide variety of olefinic remote hydrofunctionalization reactions have been realized through the synergistic combination of NiH-catalyzed chain-walking and Ni-catalyzed cross-coupling. In this Account we discuss our recent achievements in the remote hydroarylation of olefins and in asymmetric hydroarylation. 1 Introduction 2 NiH-Catalyzed Remote Hydroarylation 3 Progress in Asymmetric Catalysis 4 Conclusion