材料科学
癌症治疗
肿瘤微环境
中性粒细胞胞外陷阱
炎症
纳米技术
药物输送
免疫系统
免疫学
癌症
癌症研究
生物
医学
内科学
作者
Jiahui Zhang,Jianmei Gu,Xu Wang,Cheng Ji,Dan Yu,Maoye Wang,Jianming Pan,Hélder A. Santos,Hongbo Zhang,Xu Zhang
标识
DOI:10.1002/adma.202310318
摘要
Abstract Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer has been proposed, where N1 neutrophils exert anti‐tumor properties while N2 neutrophils display tumor‐supportive and immune‐suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re‐polarization of tumor‐promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation‐responsive and physical barrier‐crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, we comprehensively presented the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment. This review will provide a broad understanding of the potential of neutrophils in cancer therapy. This article is protected by copyright. All rights reserved
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