伏隔核
扁桃形结构
神经科学
价(化学)
化学
心理学
内科学
医学
多巴胺
有机化学
作者
Zhen Tian,Jiachen Song,Xuran Zhao,Yiming Zhou,Xi Chen,Qiumin Le,Feifei Wang,Lan Ma,Xing Liu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-11-07
卷期号:386 (6722)
标识
DOI:10.1126/science.adp7520
摘要
The structurally symmetric mammalian brain hemispheres are interconnected by commissural axons across the midline. However, the functions of interhemispheric connectivity remain largely unknown. We found that in mice, transection of the anterior commissure (AC), which connects the rostroventral forebrain, impaired avoidant behaviors. The basolateral amygdala (BLA) in the mouse projects to the contralateral nucleus accumbens (NAc) through the AC, independent of its ipsilateral projections. Aversive stimuli activated contralateral BLA-NAc projections. Positive stimuli, however, activated ipsilateral projections. Selective activation of contralateral BLA-NAc projections activated D2-positive medium spiny neurons (D2-MSNs), reduced NAc dopamine levels, and caused aversion, whereas selective activation of ipsilateral BLA-NAc projections activated D1-MSNs, increased NAc dopamine levels, and induced reward. The contralateral BLA-AC-NAc pathway is crucial for encoding negative valence, demonstrating distinct functions of intra- and interhemispheric circuits in brain physiology.
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