草酰氯
试剂
有机合成
化学
有机化学
氯化物
脱羧
甲酰化
组合化学
催化作用
作者
Leyla Mohammadkhani,Majid Μ. Heravi
标识
DOI:10.1002/slct.201900120
摘要
Abstract Oxalyl chloride, (COCl) 2 , as an inexpensive commercially available chemical is one of the most versatile applicable organic reagents in chemical transformations. It is also employed extensively in various chemical industries. It is employed in various chemical transformations such as chlorination, oxidation, reduction, dehydration, decarboxylation, and formylation reactions as well as ring cleavage of epoxides. During the past decades, numerous procedures using (COCl) 2 as reagent have been developed and published. However, its importance has largely been overlooked by the absence of a comprehensive review in chemical literature dealing with its application in organic transformations and its utilization in the chemical industry. This Review aims to provide an overview for the applications of oxalyl chloride in organic synthesis, including its physical properties, synthesis, as well as its unique roles as the reagent in organic reactions, covering the literature over the past 103 years (from 1916 to date).
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