A review on advanced formulations strategies to prevent prescription drug abuse and their impact

The growing issues with prescription drug misuse have required the development of advanced techniques like abuse-deterrent formulations (ADFs). In this abstract we have provided a comprehensive overview of these type of novel formulations and their potential impact on mitigating prescription drug misuse. ADFs is like in modifying the formulations so that it can become a challenge to misuse. Some of the examples, market products and researches are mentioned in this review like; physical and chemical barriers to prevent common abuse methods such as crushing, snorting, or injecting. By making it more tough to extract active ingredients or achieve euphoric effect, these formulations aim to deter misuse and reduce the potential for manipulation. Another innovation involves prodrugs, which require enzymatic conversion within the body to release the active drug, it will stay inactive in normal conditions which helps in prevention of misuse. We have included some combination formulations like incorporating opioid antagonists in conjunction with the API, have also increased traction. These formulations cut or block the euphoric effects of the medicine. Further advancements include specialized temper prof coating and matrix system to reduce physical manipulations. The application of ADFs has shown encouraging outcomes, including reduced abuse rates and drug diversion. However, challenges remain as determined individuals may still avoid these deterrents.