怀孕
医学
病因学
活产
加药
植入失败
免疫系统
生育率
抗体
辅助生殖技术
产科
妇科
免疫学
内科学
人口
生物
不育
环境卫生
遗传学
作者
Wael Saab,Srividya Seshadri,Changsheng Huang,Lujain Alsubki,Nak‐Ju Sung,Joanne Kwak‐Kim
摘要
Abstract Over the last few decades, the advancement in reproductive technologies and protocols to improve embryo quality through culture techniques and genetic testing to eliminate chromosomally abnormal embryos resulted in better pregnancy rates and outcomes after fertility treatments. Unfortunately, some patients still struggle with recurrent implantation failures (RIFs) and recurrent pregnancy losses (RPLs). Immune etiologies have been attributed to play an important role in some of those patients. Maintaining a pre‐conceptional anti‐inflammatory environment for implantation and pregnancy continuation yields superior results. Intravenous immunoglobulin G (IVIG) treatment has been reported to enhance reproductive outcome in patients with RIF and RPL with immune dysregulations. In this systemic review, we analyzed outcomes of IVIG trials for RIF and RPL, its mechanism of action, dosing, administration, side‐effects, and evidence for its use in women with RIF and RPL.
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