Synthesis and biological activity of novel 1-(2,3,4-trimethoxyphenyl)-2-{[5-(3,4,5-trimethoxyphenyl)-1,3,4-thiadiazol-2-yl]thio}ethanone oxime ester derivatives

Abstract magnified image In a search for new fungicide and anticancer agent with improved biological properties and different bioactivity spectrum, we designed and synthesized a series of novel oxime esters containing 1,3,4‐thiadiazole group in moderate yield starting from gallic acid. The title compounds were identified by IR, 1 H NMR, 13 C NMR and elemental analysis. The bioassay tests showed that these title compounds exhibit weak to moderate anticancer activity in vitro by MTT method.