前列腺癌
脂肪组织
肥胖
前列腺
癌症
疾病
肿瘤微环境
生物
发病机制
生物信息学
医学
内科学
肿瘤科
癌症研究
内分泌学
作者
Zeyad D. Nassar,Adel T. Aref,Dushan Miladinovic,Chui Y. Mah,Ganesh V. Raj,Andrew J. Hoy,Lisa M. Butler
出处
期刊:BJUI
[Wiley]
日期:2018-02-21
卷期号:121 (S3): 9-21
被引量:83
摘要
Emerging data have linked certain features of clinical prostate cancer ( PC a) to obesity and, more specifically, increased adiposity. Whereas the large number of clinical studies and meta‐analyses that have explored the associations between PC a and obesity have shown considerable variability, particularly in relation to prostate cancer risk, there is an accumulating weight of evidence consistently linking obesity to greater aggressiveness of disease. In probing this association mechanistically, it has been posited that peri‐prostatic adipose tissue ( PPAT ), a significant component of the prostate microenvironment, may be a critical source of fatty acids and other mitogens and thereby influences PC a pathogenesis and progression. Notably, several recent studies have identified secreted factors from both PPAT and PC a that potentially mediate the two‐way communication between these intimately linked tissues. In the present review, we summarize the available literature regarding the relationship between PPAT and PC a, including the potential biological mediators of that relationship, and explore emerging areas of interest for future research endeavours.
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