Corrosion Motivated ROS Generation Helps Endow Titanium with Broad‐Spectrum Antibacterial Abilities

Abstract Materials that spontaneously generate reactive oxygen species (ROS) possess various industrial applications, such as organocatalysis, wastewater, and waste gas government. Given that bacteria, especially the more resistant Gram‐negative (Gram‐) species, are sensitive to ROS, endowing biomaterials with ROS producing abilities may be a useful strategy to fight against bacteria. Herein a minocycline‐loaded Mg–Fe layered double hydroxides film is constructed on the surface of biomedical titanium. The prepared films possess excellent ROS generating capabilities driven by the corrosion process of titanium, which can continuously release hydroxyl radicals without external stimuli. Both Gram‐positive (Gram+) Staphylococcus aureus and (Gram‐) Escherichia coli cells can be killed by the constructed platform under the synergistic effect of the released minocycline and ROS. Besides, the in vitro cell culture assay reveals good cytocompatibility of the as‐prepared films.