[Effect of transcutaneous electric acupoints stimulation on vascular endothelial function and inflammatory factors after percutaneous coronary intervention].

To observe the effect of transcutaneous electric acupoints stimulation (TEAS) on vascular endothelial function and inflammatory factors after percutaneous coronary intervention (PCI) in patients.A total of 94 patients with coronary heart disease and undergoing PCI were randomized into a TEAS group and a sham-TEAS group, 47 cases in each one. In the TEAS group, TEAS started at unilateral Neiguan (PC6) and Ximen (PC4) 30 min before PCI till the end of PCI. In the sham-TEAS group, the procedure and persistent time were same as the TEAS group, but no electric stimulation was performed. Before treatment and at 8 h and 24 h after PCI, the levels of serum endothelin-1 (ET-1), von Willebrand factor (vWF), nitric oxide (NO), blood flow dependent diastolic function (FMD), interleukin-6 (IL-6), inteleukin-10 (IL-10), matrix metalloproteinase-9 (MMP-9) and high-sensitivity C-reactive protein (hs-CRP) were detected in the patients successively.Compared with the levels before PCI, the levels of ET-1 and vWF were all increased at 8 h and 24 h after PCI in the two groups (P<0.05) and the levels in the TEAS group were remarkably lower than those in the sham-TEAS group (P<0.05). Compared with the levels before PCI, the levels of NO and FMD at 8 h and 24 h after PCI were all reduced in the two groups (P<0.05) and the levels in the TEAS group were higher obviously than those in the sham-TEAS group (P<0.05). Compared with the levels before PCI, the levels of hs-CRP, MMP-9, IL-6 and IL-10 were all increased at 8 h and 24 h after PCI in the two groups (P<0.05); Compared with the sham-TEAS group, the levels of hs-CRP, MMP-9 and IL-6 were reduced and the level of IL-10 was increased at 8 h and 24 h after PCI in the TEAS group (P<0.05).TEAS effectively improves the vascular endothelial function and reduces serum inflammatory factors after PCI.目的：观察运用经皮穴位电刺激(TEAS)对经皮冠状动脉介入(PCI)术后患者血管内皮功能和炎性因子的影响。方法：将94例择期行PCI的冠心病患者随机分为TEAS组和假TEAS组，每组47例。TEAS组患者于PCI手术前30 min刺激单侧内关和郄门直至术毕；假TEAS组程序和持续时间与TEAS组相同，但未给予电刺激。记录患者术前、术后8 h和24 h血清内皮素-1(ET-1)、血管性假血友病因子(vWF)、一氧化氮(NO)、血流依赖性舒张功能(FMD)、白介素-6(IL-6)、白介素-10(IL-10)、基质金属蛋白酶-9(MMP-9)、超敏C反应蛋白(hs-CRP)水平。结果：与术前比较,术后8、24 h两组患者ET-1、vWF水平均升高(P<0.05)，且TEAS组明显低于假TEAS组(P<0.05)。与术前比较，两组术后8、24 h的NO、FMD水平均降低(P<0.05)，TEAS组明显高于假TEAS组(P<0.05)。与术前比较，两组患者术后8、24 h的hs-CRP、MMP-9、IL-6、IL-10含量均升高(P<0.05)；与假TEAS组比较，TEAS组术后8、24 h的hs-CRP、MMP-9、IL-6含量降低(P<0.05)，IL-10含量升高(P<0.05)。结论：TEAS可有效改善PCI术后血管内皮功能，降低血清炎性因子水平。.