生酮饮食
酮体
酮症
医学
病因学
癫痫
过剩1
内皮功能障碍
肥胖
内分泌学
内科学
生物信息学
生物
糖尿病
新陈代谢
葡萄糖转运蛋白
胰岛素
精神科
作者
Luciano Pirola,Oskar Ciesielski,Aneta Balcerczyk
标识
DOI:10.1016/j.bcp.2022.115346
摘要
The ketogenic diet (KD), a high-fat, low-carbohydrate dietary approach that is based on the induction of extensive ketone bodies (KB) metabolism, is recently receiving a lot of attention due to its application as effective intervention for multiple metabolic disorders including cardiovascular diseases. Despite its already established clinical use, especially in the treatment of drug-resistant epilepsy, GLUT1 deficiency syndromes and, in selected cases, obesity; the systemic impact of is not yet fully understood. Here, we discuss the evidence for and against the application of ketogenic diets, or ketone bodies precursors, in the etiology of hypertension and endothelial cells dysfunction. We attempt to identify the benefits and potential risks of chronic use of the ketogenic diet, also considering the molecular effects that KB exerts at multiple levels.
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