A reaction-based bright red-emitting fluorescence probe for hypochlorite detection and its biological application

Monitoring the fluctuations of endogenous ClO− in vivo is very important to understand the physiological roles of ClO− and the mechanisms of ClO− relevant diseases. Herein, a new fluorescent probe, RhB-FL exhibited excellent sensitivity and anti-interference for ClO− detection, and the detection limit was as low as 4.8 × 10−7 M. Furthermore, RhB-FL was effectively applied to detect ClO− in cells.