光动力疗法
透明质酸
细胞外基质
光敏剂
乙二醇
活性氧
肿瘤缺氧
生物物理学
材料科学
癌症研究
体内
肿瘤微环境
化学
生物化学
放射治疗
医学
外科
肿瘤细胞
有机化学
生物技术
解剖
生物
作者
Shibo Wang,Zhaoxia Chen,Fan Gao,Cheng Zhang,Mei‐Zhen Zou,Jing‐Jie Ye,Xuan Zhang,Xian‐Zheng Zhang
出处
期刊:Biomaterials
[Elsevier]
日期:2020-03-01
卷期号:234: 119772-119772
被引量:101
标识
DOI:10.1016/j.biomaterials.2020.119772
摘要
Photodynamic therapy (PDT) is a promising treatment modality for tumor suppression. However, the hypoxic state of most solid tumors might largely hinder the efficacy of PDT. Here, a functional covalent organic framework (COF) is fabricated to enhance PDT efficacy by remodeling the tumor extracellular matrix (ECM). Anti-fibrotic drug pirfenidone (PFD) is loaded in an imine-based COF (COFTTA-DHTA) and followed by the decoration of poly(lactic-co-glycolic-acid)-poly(ethylene glycol) (PLGA-PEG) to fabricate [email protected]TTA-DHTA@PLGA-PEG, or PCPP. After injected intravenously, PCPP can accumulate and release PFD in tumor sites, leading to down-regulation of ECM compenents such as hyaluronic acid (HA) and collagen I. Such depletion of tumor ECM reduces the intratumoral solid stress, a compressive force exerted by the ECM and cells, decompresses tumor blood vessels, and increases the density of effective vascular areas, resulting in significantly improved oxygen supply in tumor. Furthermore, PCPP-mediated tumor ECM depletion also enhances the tumor uptake of subsequently injected Protoporphyrinl IX (PPIX)-conjugated peptide formed nanomicelles (NM-PPIX) due to the improved enhanced permeability and retention (EPR) effect. Both the alleviated tumor hypoxia and improved tumor homing of photosensitizer (PS) molecules after PCPP treatment significantly increase the reactive oxygen species (ROS) generation in tumor and therefore realize greatly enhanced PDT effect of tumor in vivo.
科研通智能强力驱动
Strongly Powered by AbleSci AI