Cytochrome P450 Enzymes and Drug Metabolism in Humans

细胞色素P450 药物代谢 药品 生物 药物作用 表观遗传学 戒毒(替代医学) 药理学 新陈代谢 生物化学 基因 医学 病理 替代医学
作者
Mingzhe Zhao,Jingsong Ma,Mo Li,Yingtian Zhang,Bixuan Jiang,Xianglong Zhao,Cong Huai,Lu Shen,Na Zhang,Lin He,Shengying Qin
出处
期刊:International Journal of Molecular Sciences [MDPI AG]
卷期号:22 (23): 12808-12808 被引量:350
标识
DOI:10.3390/ijms222312808
摘要

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination of common clinical drugs can be attributed to one or more of the various CYPs, from the CYP families 1-3. In addition to the basic metabolic effects for elimination, CYPs are also capable of affecting drug responses by influencing drug action, safety, bioavailability, and drug resistance through metabolism, in both metabolic organs and local sites of action. Structures of CYPs have recently provided new insights into both understanding the mechanisms of drug metabolism and exploiting CYPs as drug targets. Genetic polymorphisms and epigenetic changes in CYP genes and environmental factors may be responsible for interethnic and interindividual variations in the therapeutic efficacy of drugs. In this review, we summarize and highlight the structural knowledge about CYPs and the major CYPs in drug metabolism. Additionally, genetic and epigenetic factors, as well as several intrinsic and extrinsic factors that contribute to interindividual variation in drug response are also reviewed, to reveal the multifarious and important roles of CYP-mediated metabolism and elimination in drug therapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
现代的岩完成签到 ,获得积分10
刚刚
阿萨德完成签到,获得积分10
刚刚
思源应助qibing Gu采纳,获得10
刚刚
大模型应助王蓉采纳,获得10
1秒前
Jasper应助overThat采纳,获得10
1秒前
MR_Z完成签到,获得积分10
1秒前
易清华完成签到 ,获得积分10
2秒前
lin完成签到,获得积分10
3秒前
DrKe完成签到,获得积分10
3秒前
Charming完成签到,获得积分10
4秒前
6秒前
elsalili完成签到 ,获得积分10
6秒前
FJXHXQ完成签到,获得积分20
7秒前
huihuiyve完成签到,获得积分10
8秒前
9秒前
9秒前
科研通AI2S应助雪儿采纳,获得10
10秒前
11秒前
无心的怜烟完成签到,获得积分10
12秒前
王蓉发布了新的文献求助10
13秒前
嗯嗯发布了新的文献求助10
14秒前
14秒前
万能图书馆应助李丽丽采纳,获得10
14秒前
qibing Gu发布了新的文献求助10
14秒前
小青菜完成签到,获得积分10
15秒前
xiaojcom应助汤博森采纳,获得10
15秒前
我是老大应助汤博森采纳,获得10
15秒前
李爱国应助汤博森采纳,获得10
15秒前
斯文败类应助汤博森采纳,获得10
15秒前
JXDYYZK完成签到,获得积分10
15秒前
16秒前
17秒前
hjkk完成签到,获得积分10
18秒前
整齐小猫咪完成签到,获得积分10
18秒前
你帅你有理完成签到,获得积分10
18秒前
19秒前
郑伟李完成签到,获得积分10
19秒前
21秒前
稳重飞飞完成签到,获得积分10
22秒前
哈哈发布了新的文献求助10
23秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162652
求助须知:如何正确求助?哪些是违规求助? 2813541
关于积分的说明 7900951
捐赠科研通 2473107
什么是DOI,文献DOI怎么找? 1316652
科研通“疑难数据库(出版商)”最低求助积分说明 631468
版权声明 602175