生物
TLR3型
炎症
受体
Toll样受体
伤口愈合
平衡
细胞生物学
信号转导
免疫学
先天免疫系统
免疫系统
生物化学
作者
Divya Ramnath,Elizabeth E. Powell,Glen M. Scholz,Matthew J. Sweet
标识
DOI:10.1016/j.semcdb.2016.08.014
摘要
In addition to their established roles in host defence, Toll-like Receptors (TLRs) have emerging roles in control of homeostasis, injury and wound repair. The dsRNA-sensing receptor, TLR3, has been particularly implicated in such processes in several different tissues including the skin, intestine and liver, as well as in the control of reparative mechanisms in the brain, heart and kidneys, following ischemia reperfusion injury. In this review, we provide an overview of TLR3 signalling and functions in inflammation, tissue damage and repair processes, as well as therapeutic opportunities that may arise in the future from knowledge of such pathways.
科研通智能强力驱动
Strongly Powered by AbleSci AI